Jason Snell has an introduction to Twitterrific 2.0 video up.
My first response is, wow — that is a lot of features. My favorite new feature is the reply tabs, so when you are replying to a tweet, you can change it from a new tweet, a reply, and a direct message to the user just by switching tabs. Great idea.
It certainly overcomes the largest complaint with the original Twitterrific, that it is too limited. We’ll see soon if it retains its best feature, though: simplicity in use.